Spinal Melanocytoma to Melanoma: A Case Report
Spinal Melanoctyoma transformed to Metastatic primary leptomeningeal melanoma (GNAQ Q209P)
A year from post-resection, a 57-year-old Caucasian female with a history of SMM and had undergone subtotal resection (STR) exhibited local recurrence and was treated with stereotactic body radiotherapy (SBRT) to a dose of 45 Gy in 5 fractions. While under radiotherapy, routine MRI revealed a lesion at the C7-T1 level, resulting in C7/T1 laminectomy. She was additionally treated with stereotactic radiosurgery (SRS) to 20 Gy for a tumor nodule at the right IAC. Pathological findings revealed melanoma and a GNAQ Q209P mutation. The patient continues treatment with Pembrolizumab. Her most recent imaging indicates the progression of metastatic disease throughout the spine (Figure 1).